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The use of real-time in situ mid-infared (mid-IR) analytics as a Process Analytical Technology (PAT) tool early in process development has become widespread particularly in the pharmaceutical industry in order to run information rich experiments which results in shorter project timelines. Not only does this result in meeting Quality by Design (QbD) objectives, but it also results in the ability to move processes to the manufacturing environment faster.

One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.

Today, the chemical industry faces major challenges including globalization, environmental regulation, and shortening product life cycle. Meeting these challenges requires alternative approaches towards reducing costs and improving the environmental and economical profile of chemical processes. Breakthroughs in process operations and process modeling have been necessary for achieving energy and material efficiency gains. These breakthroughs allow real time in situ process monitoring, characterization, and accurate control.

The ReactIR™ flow cell is presented as a convenient inline analytical tool for continuous flow chemistry processing. The flow cell, operated with ATR technology, is attached inline using standard Omnifit® connections. With the established iC IR 4.0 software the consumption of reagents and formation of products can be monitored in real-time, allowing for rapid optimization. Unstable reactive intermediates can also be observed in situ, giving mechanistic insight to complex transformations.

Measuring pH in petroleum refining processes is vital in corrosion protection. Also, in several processes pH is an important control parameter. However, when it comes to reliability, many pH analyzers show a poor track record in refinery applications and are therefore often ignored by Operations. The resulting downtime due to equipment failure and the uncontrolled consumption of chemicals, leads to severe profit loss.

Real-time in situ FTIR analysis has become a standard tool in the chemical and pharmaceutical industries for providing information rich data that allows a more thorough understanding of reactions during the development and scale-up of chemical processes.

The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, these now well structured and understood methodologies have yet to be incorporated into the standard pharmaceutical crystallization development due to time and calibration/statistical analysis experience. In this webinar, a method will be presented which facilitates the calibration free use of in situ ATR-FTIR spectra for the production and control of qualitative supersaturation trajectories.

Measuring systems based on optical technologies provide important information for process control and quality assurance purpose. Typical visual parameters are clarity, turbidity, and color of wort and beer. Recently dissolved oxygen (DO) measuring systems based on an optical principle have been made available to monitor the DO level in separation, blending and filling processes. Learn about measurement principles, applications and related benefits such as minimized operating costs and increased production uptime.

Measuring systems based on amperometric technology particularly well suited for the measurement of gaseous oxygen in blanketing, inertization and off-gas monitoring applications. Because they are insensitive to moisture and dust, they do not require any gas sampling system and can be installed directly into the process gas stream, increasing the safety of the installation by measuring there, where it matters most. Not only are amperometric systems able to accurately track the oxygen level in the process, but they are also more convenient to maintain than other current measurement systems such as paramagnetic and Zirconium Dioxide ZrO2) systems. Instead of mandatory maintenance breaks of at least one day, amperometric systems can be safely extracted from a continuous process and maintenance can be performed in two minutes.

Previously, the use of small scale reactors was the most powerful technique to perform chemical reactions for kinetic and thermodynamic screening in early stage process development. Now the combination of thermal data with in situ IR spectroscopy information provides thorough process understanding and simplifies process characterization substantially. This webinar will demonstrate the importance of detailed kinetics information at an early stage of the chemical process design. Simultaneous measurement of the heat flow and concentration profiles offer an in-depth insight into complex reactions and can reveal effects that are not detectible from a standalone technique.

Breakthroughs in process operations and modeling are necessary to achieve energy and material efficiency gains supporting shorter development and scale-up times while improving safety and the environmental and economical profile of chemical processes at the same time. In parts, these breakthroughs are made possible thanks to the use of Process Analytical Techniques (PAT) and reactor systems designed for real-time in situ process monitoring and accurate process control, both at lab and plant scale. In this webinar, case studies will be presented exploring the use of real time calorimetry as a process analytical tool mimicking operating conditions of industrial reactors at lab scale – to prevent batch failures at plant scale.

This two part crystallization webinar series is based on an award winning paper presented at the 16th International Process Development Conference. The webinar series focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.

Since the FDA revolutionary PAT guideline in 2004, the industry has talked non-stop about the potential of PAT (Process Analytical Technology) and more recently, QbD (Quality by Design). PAT is an enabler of the concept of QbD. This webinar will focus on new technologies used to assist the control of pH, dissolved oxygen and conductivity in up- and downstream bioprocesses.

Peptide libraries are widely investigated and routinely screened for their drug-like properties. Synthesis using resins or solid supports is a favorite route for researchers performing peptide synthesis. However, synthesis and subsequent purification are major bottlenecks encountered during synthesis of peptide libraries. This webinar examines challenges related to the synthesis of peptide libraries and will discuss various applications including the synthesis of cyclic peptides employing a unique safety-catch linker, which enables the production of diverse libraries for biological screening.

Relative concentration is sufficient for reaction progression information such as initiation, intermediate formation and endpoint. However, the ability to predict absolute concentration in real-time is sometimes desired or essential, especially during production monitoring, and for monitoring and controlling continuous processes. Part IV discusses the application of quantitative analysis using real-time in situ FTIR focusing on strategies that produce the best quantitative results for the desired outcome. Software tools for quantitative method evaluation will also be covered. This is Part IV of the webinar series - Introduction to Real-time In Situ FTIR for Rapid Reaction Progression Determination and Reaction Characterization.

This on-demand webinar will focus on how to study the following critical particle and droplet-based process inline without the need for sampling: - Understand asphaltene precipitation and deposition in crude oil - Improve oil-water and water-oil separation through in-process droplet characterization - Minimize downtime and optimize separation efficiency by monitoring particle distributions in drilling fluids - Visualize gas hydrate formation to ensure consistent flow-rates - Study inorganic precipitation to prevent scaling

This webinar introduces the use of FTIR for reaction analysis and includes a comparison to other well known spectroscopic techniques. The method of measurement and probe and sensor options available will be discussed as well as best practices on how to collect high quality data that will facilitate easy interpretation.

Real-time in situ FTIR is used to study reaction progression, analyze reaction kinetics and to elucidate reaction mechanism and pathway. This free on-demand webinar series covers several recent publications by academia illustrating how real-time in situ FTIR was used to help advance the fundamental understanding of organic chemistry.

Presentation will show how WeylChem, a global fine chemical company specializing in custom synthesis, avoids process safety and thermal hazard analysis risks by studying heat generation. Your guest presenter, Kevin Drost, is a Senior Process Chemist at WeylChem. A scalable and cost efficient synthetic route to diformylarylbenzene was investigated. It involved a double formylation step that relies on the use of 2-nitropropane as a primary reagent. Due to the inherent energetic nature of nitroalkanes, a process safety assessment was necessary.

Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased . Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore, at the heart of any scale-up chemical process, there has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process.